Functional genomics atlas of synovial fibroblasts defining rheumatoid arthritis heritability.

Xiangyu GeMojca Frank-BertonceljKerstin KleinAmanda McGovernTadeja KuretMiranda HoutmanBlaž BurjaRaphael MicheroliChenfu ShiMiriam MarksAndrew FilerChristopher D BuckleyGisela OrozcoOliver DistlerAndrew P MorrisPaul MartinStephen EyreCaroline Ospelt

Published in: Genome biology (2021)

Overall, our research provides the first direct evidence for a causal role of FLS in the genetic susceptibility for RA accounting for up to a quarter of RA heritability.

Keyphrases

rheumatoid arthritis
disease activity
single cell
ankylosing spondylitis
interstitial lung disease
genome wide
systemic lupus erythematosus
extracellular matrix
gene expression
systemic sclerosis