Cortical microstructural changes predict tau accumulation and episodic memory decline in older adults harboring amyloid.
Geoffroy GagliardiElena Rodriguez-VieitezVictor MontalJorge SepulcreIbai DiezCristina LoisBernard HanseeuwAaron P SchultzMichael J ProperziKathryn V PappGad A MarshallJuan ForteaKeith A JohnsonReisa A SperlingPatrizia VanniniPublished in: Communications medicine (2023)
The combination of amyloidosis and elevated cMD in the entorhinal cortex may help identify individuals at short-term risk of tau accumulation and Alzheimer's Disease-related episodic memory decline, suggesting utility in clinical trials.