The Acute Effect of Skin Preheating on Capsaicin-Induced Central Sensitization in Humans.
Lukas D LindeJohn Z SrbelyPublished in: Pain practice : the official journal of World Institute of Pain (2019)
Preheating amplifies the sensitizing effect of topical capsaicin within 30 minutes of application. The heat-capsaicin technique may be employed to assess differing magnitudes of CS induction and enables future studies investigating the development and progression of CS in humans.