Bifid T waves on the ECG and genetic variation in calcium channel voltage-dependent beta 2 subunit gene (CACNB2) in acute Kawasaki disease.

Jun OyamadaChisato ShimizuJihoon KimMatthew R WilliamsEileen PngMartin L HibberdAdriana H TremouletJames C PerryJane C Burns

Published in: Congenital heart disease (2018)

This genotype/phenotype association study uncovered a variant in CACNB2 that may be associated with both KD susceptibility and bifid T waves, a novel signature of altered myocardial repolarization. The present study combined with published reports suggests that genetic variants in calcium channels and intracellular calcium signaling play a prominent role in shaping susceptibility to KD.

Keyphrases

gene expression
emergency department
systematic review
heart failure
copy number
dna methylation
left ventricular
genome wide
heart rate
atrial fibrillation
reactive oxygen species
drug induced
adverse drug
aortic dissection