Cobalt-Catalyzed Deprotection of Allyl Carboxylic Esters Induced by Hydrogen Atom Transfer.

Nan LiYizhen GuiMengqi ChuMengdi YouXiaohan QiuHejia LiuShiang WangMeng Deng Baoming Ji

Published in: Organic letters (2021)

A brief, efficient method has been developed for the removal of the allyl protecting group from allyl carboxylic esters using a Co(II)/TBHP/(Me2SiH)2O catalytic system. This facile strategy displays excellent chemoselectivity, functional group tolerance, and high yields. This transformation probably occurs through the hydrogen atom transfer process, and a Co(III)-six-membered cyclic intermediate is recommended.

Keyphrases

electron transfer
molecular dynamics
reduced graphene oxide
visible light
metal organic framework
room temperature
gold nanoparticles