In vitro and in vivo efficacies of Dectin-1-Fc(IgG)(s) fusion proteins against invasive fungal infections.
Susana Ruiz MendozaSusie Coutinho LiedkeClaudia Rodriguez de La NovalMarina da Silva FerreiraKamilla Xavier GomesLeandro HonoratoLeonardo NimrichterJosé Mauro PeraltaAllan Jefferson GuimarãesPublished in: Medical mycology (2022)
Mycoses have increased worldwide, and new efficient therapeutics are needed. Passive immunizations targeting universally the fungal cell would allow early interventions without the species-level diagnosis. Lectins with affinity to carbohydrates could be used to engineer 'antibody-like' strategies.