Evolution and transmission of antibiotic resistance is driven by Beijing lineage Mycobacterium tuberculosis in Vietnam.
Matthew SilcocksXuling ChangNguyen Thuy Thuong ThuongYouwen QinDang Thi Minh HaPhan Vuong Khac ThaiSrinivasan VijayDo Dang Anh ThuVu Thi Ngoc HaHoang Ngoc NhungNguyen Huu LanNguyen Thi Quynh NhuDavid EdwardsArtika NathKym PhamNguyen Duc BangTran Thi Hong ChauGuy ThwaitesA Dorothee HeemskerkChiea Chuen KhorYik Ying TeoMichael InouyeRick Twee-Hee OngMaxine CawsKathryn E HoltSarah J DunstanPublished in: Microbiology spectrum (2023)
genetic lineage plays in determining the likelihood of resistance evolution. This study offers insight into these questions by assessing the dynamics of resistance evolution in a high-burden Southeast Asian setting with a diverse lineage composition. It demonstrates that there are clear lineage-specific differences in the dynamics of resistance acquisition and transmission and shows that different lineages evolve resistance via characteristic mutational pathways.