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Tris(4-azidophenyl)methanol - a novel and multifunctional thiol protecting group.

Xujun QiuJulian BrückelChristoph ZippelMartin NiegerFrank BiedermannStefan Bräse
Published in: RSC advances (2023)
The novel tris(4-azidophenyl)methanol, a multifunctionalisable aryl azide, is reported. The aryl azide can be used as a protecting group for thiols in peptoid synthesis and can be cleaved under mild reaction conditions via a Staudinger reduction. Moreover, the easily accessible aryl azide can be functionalised via copper-catalysed cycloaddition reactions, providing additional opportunities for materials chemistry applications.
Keyphrases
  • carbon dioxide
  • drug delivery
  • metal organic framework