Untargeted metabolomics yields insight into ALS disease mechanisms.
Stephen A GoutmanJonathan BossKai GuoFadhl M AlakwaaAdam PattersonSehee KimMasha Georges SavelieffJunguk HurEva L FeldmanPublished in: Journal of neurology, neurosurgery, and psychiatry (2020)
In our analysis, ALS led to significant metabolic pathway alterations, which had correlations to known ALS pathomechanisms in the basic and clinical literature, and may represent important targets for future ALS therapeutics.