Ibuprofen mediates histone modification to diminish cancer cell stemness properties via a COX2-dependent manner.

Wenzhi ShenXiaoyuan ZhangRenle DuWenjuan GaoJuan WangYonghua BaoWancai YangNa LuoJianjun Li

Published in: British journal of cancer (2020)

The aforementioned findings suggest a molecular model that explains how ibuprofen diminishes cancer cell stemness properties. These may provide novel targets for therapeutic strategies involving ibuprofen in the prevention of cancer progression.

Keyphrases

stem cells
epithelial mesenchymal transition
postoperative pain
papillary thyroid
squamous cell
single molecule
signaling pathway