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Multiparametric MRI for prediction of treatment response to neoadjuvant FOLFIRINOX therapy in borderline resectable or locally advanced pancreatic cancer.

Ji Hun KangSeung Soo LeeJin Hee KimJae Ho ByunHyoung Jung KimChanghoon YooKyu-Pyo KimBaek-Yeol RyooSong Cheol Kim
Published in: European radiology (2020)
• Baseline ΔR1 was an independent predictor for tumor response (adjusted odds ratio, 31.07; p = 0.008) and progression-free survival (adjusted hazard ratio, 0.40; p = 0.033) in patients with borderline resectable or locally advanced pancreatic ductal adenocarcinoma receiving neoadjuvant FOLFIRINOX therapy. • The criterion of baseline ΔR1 value ≥ 1.31 s-1 allowed for the prediction of favorable tumor response and survival outcome after neoadjuvant FOLFIRINOX therapy.
Keyphrases
  • locally advanced
  • rectal cancer
  • neoadjuvant chemotherapy
  • squamous cell carcinoma
  • radiation therapy
  • phase ii study
  • free survival
  • magnetic resonance imaging
  • stem cells
  • clinical trial
  • magnetic resonance