Monocarboxylate transporter 1 and the vulnerability of oligodendrocyte lineage cells to metabolic stresses.

Peng ZhouTeng GuanZhao JiangMike NamakaQing-Jun HuangJi-Ming Kong

Published in: CNS neuroscience & therapeutics (2017)

Taken together, this study shows that MCT1 plays a role in the responses of OPCs and OLs to metabolic and ischemic stresses and suggests that redistribution of energy substrates is a determinant in white matter injury.

Keyphrases

white matter
induced apoptosis
climate change
cell cycle arrest
multiple sclerosis
endoplasmic reticulum stress
cell death
signaling pathway
cell proliferation