The tumor cell-intrinsic cGAS-STING pathway is associated with the high density of CD8 + T cells after chemotherapy in esophageal squamous cell carcinoma.

Akira MatsuishiShotaro NakajimaAkinao KanetaKatsuharu SaitoSatoshi FukaiMei SakumaHideaki TsumurayaHirokazu OkayamaMotonobu SaitoKosaku MimuraAzuma NireiTomohiro KikuchiHiroyuki HanayamaZenichiro SazeWataru SakamotoTomoyuki MommaKoji Kono

Published in: Esophagus : official journal of the Japan Esophageal Society (2024)

Our findings suggest that the tumor cell-intrinsic cGAS-STING pathway might contribute to chemotherapy-induced immune cell activation in the ESCC TME.

Keyphrases

high density
chemotherapy induced
single cell
cell therapy
stem cells
squamous cell carcinoma
radiation therapy
mesenchymal stem cells
innate immune