lncRNA HOTAIR overexpression induced downregulation of c-Met signaling promotes hybrid epithelial/mesenchymal phenotype in hepatocellular carcinoma cells.
Hande TopelEzgi BagirsakciDehan ComezGulsun BagciGulcin Cakan-AkdoganNeşe AtabeyPublished in: Cell communication and signaling : CCS (2020)
Our work provides the first evidence suggesting a role for lncRNA HOTAIR in the modulation of c-Met to promote hybrid E/M phenotype. The balance between lncRNA HOTAIR and c-Met might be critical for cell fate decision and metastatic potential of HCC cells. Video Abstract.
Keyphrases
- cell fate
- tyrosine kinase
- long non coding rna
- long noncoding rna
- cell proliferation
- induced apoptosis
- small cell lung cancer
- squamous cell carcinoma
- cell cycle arrest
- stem cells
- signaling pathway
- high glucose
- bone marrow
- diabetic rats
- transcription factor
- oxidative stress
- cell death
- decision making
- endoplasmic reticulum stress
- climate change