AUY922 induces retinal toxicity through attenuating TRPM1.

Che-Hung ShenChi-Che HsiehKuan-Ying JiangChih-Yu LinNai-Jung ChiangTing-Wei LiChun-Ting YenWan-Ju ChenDaw-Yang HwangLi-Tzong Chen

Published in: Journal of biomedical science (2021)

Our study demonstrates the pathology of AUY922-induced retinal toxicity in vivo. TRPM1 is an HSP90 client, regulates photoreceptor morphology and function, and mediates AUY922-induced cytotoxicity.

Keyphrases

high glucose
optical coherence tomography
diabetic retinopathy
oxidative stress
drug induced
endothelial cells
heat shock protein