Partitioned glioma heritability shows subtype-specific enrichment in immune cells.

Quinn T OstromJacob EdelsonJinyoung ByunYounghun HanBen KinnersleyBeatrice MelinRichard S HoulstonMichelle Monjenull nullKyle M WalshChristopher I AmosMelissa L Bondy

Published in: Neuro-oncology (2021)

This analysis identifies putative new associations between glioma and autoimmune conditions with genomic architecture that is inversely correlated with that of glioma and that T cells, NK cells, and myeloid cells are involved in mediating glioma predisposition. This provides further evidence that increased activation of the acquired immune system may modify individual susceptibility to glioma.

Keyphrases

nk cells
induced apoptosis
multiple sclerosis
acute myeloid leukemia
immune response
dna methylation
oxidative stress
cell death
copy number
endoplasmic reticulum stress