Endogenous glucagon-like peptide- 1 and 2 are essential for regeneration after acute intestinal injury in mice.
Rasmus Hytting-AndreasenEmilie Balk-MøllerBolette HartmannJens PedersenJohanne Agerlin WindeløvJens Juul HolstHannelouise KissowPublished in: PloS one (2018)
The ablation of L-cells leads to severe mucositis and insufficient intestinal healing, shown by severe body weight loss and lack of compensatory hyperproliferation in the recovery phase. Co-treatment with exendin-4 and teduglutide could prevent this. Because both peptides were needed, we can conclude that both GLP-1 and GLP-2 are essential for intestinal healing in mice.
Keyphrases
- weight loss
- induced apoptosis
- high fat diet induced
- early onset
- stem cells
- bariatric surgery
- cell cycle arrest
- radiation induced
- drug induced
- type diabetes
- roux en y gastric bypass
- cell death
- radiation therapy
- signaling pathway
- skeletal muscle
- body mass index
- wild type
- metabolic syndrome
- insulin resistance
- gastric bypass
- cell proliferation
- radiofrequency ablation
- amino acid
- smoking cessation