Glucose/Fructose Delivery to the Distal Nephron Activates the Sodium-Chloride Cotransporter via the Calcium-Sensing Receptor.
Jessica Paola Bahena-LopezLorena Rojas-VegaMaría Chávez-CanalesSilvana Bazua-ValentiRocío Bautista-PérezJu-Hye LeeMagdalena MaderoNatalia Vazquez-ManjarrezIvan Alquisiras-BurgosArturo Hernandez-CruzMaría Castañeda-BuenoDavid H EllisonGerardo GambaPublished in: Journal of the American Society of Nephrology : JASN (2022)
Glycosuria or fructosuria was associated with increased NCC, SPAK, and WNK4 phosphorylation in a CaSR-dependent manner.