KCa1.1 and Kv1.3 channels regulate the interactions between fibroblast-like synoviocytes and T lymphocytes during rheumatoid arthritis.

Mark R TannerMichael W PenningtonSatendra S ChauhanTeresina LaragionePércio S GulkoChristine Beeton

Published in: Arthritis research & therapy (2019)

Our results demonstrate the importance of KCa1.1 and Kv1.3 in regulating FLS and TEM cells during RA, as well as the value of combined therapies targeting both of these cell types to treat RA.

Keyphrases

rheumatoid arthritis
disease activity
induced apoptosis
ankylosing spondylitis
cell cycle arrest
interstitial lung disease
image quality
single cell
systemic lupus erythematosus
dual energy
cancer therapy
endoplasmic reticulum stress
computed tomography
signaling pathway
stem cells
magnetic resonance
drug delivery