Elevated monocytic myeloid-derived suppressor cells positively correlate with infection frequency in children with RRTIs.

Jianjian JiLishun RenYuling LiuMin ZhengHuazhong FangHui XuHuizhen HeMin ZhangXianzheng WangJinjun ShanYayi Hou

Published in: European journal of immunology (2021)

In children with recurrent respiratory tract infections (RRTIs), the percentages and numbers of monocytic myeloid-derived suppressor cells (MDSCs) were elevated. The elevated MDSCs positively correlate with respiratory tract infection frequency in RRTIs children. The elevated MDSCs can inhibit CD8+ T-cells proliferation in RRTIs children.

Keyphrases

respiratory tract
young adults
induced apoptosis
cell cycle arrest
signaling pathway
cell death
endoplasmic reticulum stress
pi k akt