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Inhibitory Effect of CAPE and Kaempferol in Colon Cancer Cell Lines-Possible Implications in New Therapeutic Strategies.

Liviuta BudisanDiana GuleiAncuta JurjCornelia BraicuOana ZanoagaRoxana Maria CojocneanuLaura PopLajos RadulyAlexandru BarbatAlin Iulian MoldovanCristian Silviu MoldovanAdrian-Bogdan ȚiguCalin IonescuAtanas Georgiev AtanasovAlexandru IrimieAlina-Andreea Zimta
Published in: International journal of molecular sciences (2019)
Our findings indicate that CAPE and Kaempferol have the ability to negatively influence the development and advancement of colon cancer in vitro by specifically altering the cells at the molecular level; this activity can be exploited in possible adjuvant therapies once the optimal dose concentration with minimal side effects but with cancer inhibitory activity is set in vivo.
Keyphrases
  • south africa
  • induced apoptosis
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  • cell cycle arrest
  • early stage
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  • endoplasmic reticulum stress
  • oxidative stress
  • young adults
  • squamous cell carcinoma
  • lymph node metastasis