Upstream anticoagulation in patients with ST-segment elevation myocardial infarction: a systematic review and meta-analysis.
Francisco AlbuquerqueDaniel A GomesJorge FerreiraPedro de Araújo GonçalvesPedro M LopesJoão PresumeRui Campante TelesManuel de Sousa AlmeidaPublished in: Clinical research in cardiology : official journal of the German Cardiac Society (2023)
Upstream anticoagulation was associated with a significantly lower risk of 30-day all-cause mortality, incidence of in-hospital CS, and improved reperfusion of the infarct-related artery (IRA). These findings were not accompanied by an increased risk of major bleeding, suggesting an overall clinical benefit of early anticoagulation in STEMI. These results require confirmation in a dedicated randomized clinical trial.
Keyphrases
- st segment elevation myocardial infarction
- atrial fibrillation
- percutaneous coronary intervention
- acute myocardial infarction
- venous thromboembolism
- st elevation myocardial infarction
- acute coronary syndrome
- coronary artery disease
- healthcare
- heart failure
- risk factors
- clinical trial
- brain injury
- cerebral ischemia
- acute ischemic stroke