Neuropathological Examination of Mice Chronically Exposed to Secondhand Smoke.
Leilani A LopesConor DavenportEstefania Ramos TorresAnna ChlebowskiAnna MikamiJacob RaberEileen Ruth TorresGlen KisbyPublished in: Military medicine (2023)
These studies demonstrate that oxidative DNA damage (8-oxoG) was elevated and oxidative DNA repair (Ape1 and Ogg1) was altered in the brain of SHS exposed mice. In addition, activated astrocytes (i.e., glial fibrillary acidic protein) were also observed in the brain of SHS exposed mice. Therefore, SHS induces both oxidative DNA damage and repair as well as inflammation as possible underlying mechanism(s) of the cognitive decline and metabolic changes that were observed in chronically exposed mice. A better understanding of how chronic exposure to SHS induces cognitive dysfunction among military personnel could help improve the combat readiness of U.S. soldiers as well as reduce the financial burden on the DOD and veterans' families.
Keyphrases
- dna damage
- dna repair
- cognitive decline
- high fat diet induced
- oxidative stress
- resting state
- healthcare
- white matter
- type diabetes
- adipose tissue
- spinal cord injury
- wild type
- multiple sclerosis
- functional connectivity
- neuropathic pain
- health insurance
- brain injury
- small molecule
- skeletal muscle
- cerebral ischemia
- affordable care act