Higher BMI, but not obesity-related genetic polymorphisms, correlates with lower structural connectivity of the reward network in a population-based study.
Frauke BeyerRui ZhangMarkus ScholzKerstin WirknerMarkus LoefflerMichael StumvollArno VillringerA Veronica WittePublished in: International journal of obesity (2005) (2020)
Here, we provide evidence that higher BMI correlates with lower reward network structural connectivity. This result is in line with previous findings of obesity-related decline in white matter microstructure. We did not observe an association of variants in FTO or near DRD2 receptor with reward network structural connectivity in this population-based cohort with a wide range of BMI and age. Future research should further investigate the link between genetics, obesity and fronto-striatal structural connectivity.
Keyphrases
- white matter
- weight gain
- resting state
- insulin resistance
- functional connectivity
- multiple sclerosis
- metabolic syndrome
- weight loss
- body mass index
- type diabetes
- high fat diet induced
- adipose tissue
- skeletal muscle
- gene expression
- prefrontal cortex
- current status
- copy number
- parkinson disease
- genome wide
- dna methylation
- physical activity