Combined Connectomics, MAPT Gene Expression, and Amyloid Deposition to Explain Regional Tau Deposition in Alzheimer's Disease.

Lukai ZhengAnna RubinskiJannis DenneckeYing LuanRuben SmithOlof StrandbergErik StomrudRik OssenkoppeleDiana Otero SvaldiIxavier Alonzo HigginsSergey ShcherbininMichael J PontecorvoOskar Hansson Nicolai Franzmeier Michael Ewersnull null

Published in: Annals of neurology (2023)

Across three study samples, combining the functional connectome and molecular properties substantially enhanced the explanatory power compared to single modalities, providing a valuable tool to explain regional susceptibility to tau deposition in AD. This article is protected by copyright. All rights reserved.

Keyphrases

gene expression
cerebrospinal fluid
dna methylation
cognitive decline
single molecule
resting state