Circulating CD34+ cells of primary myelofibrosis patients contribute to myeloid-dominant hematopoiesis and bone marrow fibrosis in immunodeficient mice.
Noriyuki SaitoTakuji YamauchiNoriaki KawanoRintaro OnoShuro YoshidaToshihiro MiyamotoTomohiko KamimuraLeonard D ShultzYoriko SaitoKatsuto TakenakaKazuya ShimodaMine HaradaKoichi AkashiFumihiko IshikawaPublished in: International journal of hematology (2021)
A patient-derived xenotransplantation (PDX) model of PMF allows in vivo examination of disease onset and propagation originating from immature CD34+ cells and will support the investigation of pathogenesis and development of therapeutic modalities for the disorder.
Keyphrases
- bone marrow
- induced apoptosis
- cell cycle arrest
- end stage renal disease
- ejection fraction
- mesenchymal stem cells
- chronic kidney disease
- endoplasmic reticulum stress
- prognostic factors
- cell death
- signaling pathway
- dendritic cells
- type diabetes
- oxidative stress
- cell proliferation
- acute myeloid leukemia
- immune response
- patient reported outcomes
- high fat diet induced
- nk cells