Genetic prediction of impulse control disorders in Parkinson's disease.

Daniel WeintraubMarijan PosaviPierre FontanillasThomas Francis TropeaEugenia MamikonyanEunran SuhJohn Q TrojanowskiPaul CannonVivianna M Van Deerlinnull nullAlice S Chen-Plotkin

Published in: Annals of clinical and translational neurology (2022)

In this multi-cohort, international study, we developed an easily computed clinico-genetic tool, the ICD-RS, that substantially enriches for subgroups of PD at very high versus very low risk for ICD, enabling pharmacogenetic approaches to PD medication selection.

Keyphrases

genome wide
copy number
computed tomography
gene expression
magnetic resonance
diffusion weighted imaging
contrast enhanced