A clinical case-control comparison of epidermal innervation density in Rett syndrome.
Frank J SymonsChantel C BarneyBreanne J ByiersBrian D McAdamsShawn X Y L FosterTimothy J FeymaGwen Wendelschafer-CrabbWilliam R KennedyPublished in: Brain and behavior (2019)
Given the clinical phenotype of disrupted sensory function along with diagnostic criteria specific to cold hands/feet and insensitivity to pain, our preliminary observations of ENF peptidergic fiber density differences warrants further investigation of the peripheral neurobiology in RTT.