Modulation of Alveolar Macrophage Activity by Eugenol Attenuates Cigarette-Smoke-Induced Acute Lung Injury in Mice.
Maria Clara Barbosa-de-OliveiraPaolo Oliveira-MeloMarcos Henrique Gonçalves da SilvaFlávio Santos da SilvaFelipe Andrade Carvalho da SilvaBruno Vinicios Silva de AraujoMoacir Franco de OliveiraAristides Tadeu CorreiaSidnei Miyoshi SakamotoSamuel Dos Santos ValençaManuella LanzettiMartina Christina Schmidt-DenglerEmanuel Kennedy-FeitosaPublished in: Antioxidants (Basel, Switzerland) (2023)
This study investigates the role of eugenol (EUG) on CS-induced acute lung injury (ALI) and how this compound is able to modulate macrophage activity. C57BL/6 mice were exposed to 12 cigarettes/day/5days and treated 15 min/day/5days with EUG. Rat alveolar macrophages (RAMs) were exposed to CSE (5%) and treated with EUG. In vivo, EUG reduced morphological changes inflammatory cells, oxidative stress markers, while, in vitro, it induced balance in the oxidative stress and reduced the pro-inflammatory cytokine release while increasing the anti-inflammatory one. These results suggest that eugenol reduced CS-induced ALI and acted as a modulator of macrophage activity.