Green synthesis of nonprecious metal-doped copper hydroxide nanoparticles for construction of a dopamine sensor.
Masoumeh GhalkhaniAzam Anaraki FiroozMina GhanbariMaryam GhanbariBindu PatanairSabu ThomasPublished in: Future medicinal chemistry (2021)
Background: Copper oxide nanoparticles doped with nonprecious metal species (Ni and Mn) were synthesized. Method: A glassy carbon electrode (GCE) was modified by drop-casting of nanostructure suspensions, constructing Ni:Cu(OH)2/GCE, Mn:Cu(OH)2/GCE and Cu(OH)2/GCE. Results: The voltammetric oxidation of dopamine (DA) by the constructed electrodes confirmed that the electrocatalytic oxidation of DA is a reversible, pH-dependent, diffusion-controlled process; the best response was obtained by Mn:Cu(OH)2/GCE. A sensitive calibration graph (0.664 μA/μM) was produced for DA in the concentration range of 0.3-10.0 μM, with a detection limit of 79 nM using Mn:Cu(OH)2/GCE. Conclusion: The Mn:Cu(OH)2/GCE possessed an accurate response toward DA with an acceptable selectivity, stability and antifouling effect, revealing the applicability of the Mn:Cu(OH)2/GCE for DA analysis in biological samples.
Keyphrases
- metal organic framework
- oxide nanoparticles
- aqueous solution
- transition metal
- room temperature
- reduced graphene oxide
- hydrogen peroxide
- photodynamic therapy
- high resolution
- metabolic syndrome
- uric acid
- convolutional neural network
- liquid chromatography
- nitric oxide
- solid state
- prefrontal cortex
- deep learning
- tandem mass spectrometry
- simultaneous determination
- ionic liquid
- real time pcr