Voltage modulates the effect of μ-receptor activation in a ligand-dependent manner.
Julia G RulandSina B KirchhoferSebastian KlindertChris P BaileyMoritz BünemannPublished in: British journal of pharmacology (2020)
Our results indicate a strong ligand-dependent modulation of μ receptor activity by the membrane potential, suggesting preferential activity of morphine in neurons with high neuronal activity.