Pharmacodynamic assessment of mycophenolic acid in resting and activated target cell population during the first year after renal transplantation.
Rolf Anton KlaasenStein BerganSara BremerKristine HoleChristine Berg NordahlAnders Mikal AndersenKarsten MidtvedtMorten Heier SkaubyNils Tore VethePublished in: British journal of clinical pharmacology (2020)
The inhibitory effect of MPA was stronger in stimulated PBMC. Nonstimulated PBMC became less sensitive to MPA during the first year after TX. Early IMPDH capacity appeared to be predictive of dose reductions.