WWP2 drives the progression of gastric cancer by facilitating the ubiquitination and degradation of LATS1 protein.
Jianping ZouLing ZhouYi LeZhi FangMin ZhongFengting NieXianpin WeiXiaomei ZhangZhen ChenLingling CaiHeng WangJianping XiongZiling FangXiaojun XiangPublished in: Cell communication and signaling : CCS (2023)
Our results define the WWP2-LATS1 axis as a critical regulatory mechanism of the Hippo-YAP1 pathway that promotes GC development and progression. Video Abstract.
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