Somatotropic-Testicular Axis: A crosstalk between GH/IGF-I and gonadal hormones during development, transition, and adult age.

Riccardo Pofi Francesco Carlomagno Biagio Cangiano George A Kanakis Carlotta Pozza Emilia Sbardella Andrea M Isidori Csilla Krausz Daniele Gianfrilli

Published in: Andrology (2020)

The role of GH-IGF-I in testicular development remains largely unexplored. However, it is important to evaluate gonadic development in children with GHD. Additionally, HPS axis function should be evaluated in children with urogenital malformation or gonadal development alterations. Correct diagnosis and prompt therapeutic intervention are needed for healthy puberty, attainment of complete gonadal development during transition age, and fertility potential in adulthood.

Keyphrases

depressive symptoms
growth hormone
binding protein
cell proliferation
risk assessment
climate change
pi k akt