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Eccrine Poroma: Pathogenesis, New Diagnostic Tools and Association with Porocarcinoma-A Review.

Eirini KyrmanidouChristina FotiadouChristina KemanetziMyrto-Georgia TrakatelliAnastasia TrigoniAikaterini PatsatsiZoe ApallaElisabeth Lazaridou
Published in: Diagnostics (Basel, Switzerland) (2023)
Eccrine poroma (EP) is a relatively rare benign adnexal neoplasm that usually affects elderly patients. Its pathogenesis is still under investigation, but recent gene studies have revealed gene fusions as key incidences resulting in oncogenetic pathways. It often presents as a solitary, firm papule, mostly asymptomatic, located on the soles or palms. Due to its clinical and dermoscopic variability, it is characterized as the great imitator. We performed a literature review, aiming to summarize current data on the pathogenetic mechanisms, new dermoscopic features, and novel diagnostic tools that may aid in early diagnosis and proper management of this rare adnexal tumor. Furthermore, we reviewed the possible pathogenetic associations between EP and its malignant counterpart, namely eccrine porocarcinoma. This systematic approach may aid in understanding the pathogenetic mechanisms and how to use novel histopathologic markers and imaging methods to overcome the diagnostic dilemma of this rare tumor.
Keyphrases
  • copy number
  • genome wide
  • high resolution
  • genome wide identification
  • case report
  • low grade
  • single cell
  • gene expression
  • dna methylation
  • big data
  • mass spectrometry
  • photodynamic therapy
  • high grade