The effects of letrozole-induced maternal hyperandrogenism on sexual behaviors, testicular histology, and serum biochemical traits in male offspring rats: An experimental study.

Zahra ShaabanAmin DerakhshanfarMohammad Reza Jafarzadeh ShiraziMohammad Javad ZamiriJavad MoayediMahjoob VahediAbouzar Valizadeh

Published in: International journal of reproductive biomedicine (2023)

Maternal exposure to letrozole can adversely affect the reproductive and metabolic performance of male offspring rats, suggesting an incomplete sex differentiation.

Keyphrases

polycystic ovary syndrome
high fat diet
birth weight
pregnancy outcomes
insulin resistance
early breast cancer
high glucose
genome wide
mental health
type diabetes
drug induced
dna methylation
gene expression
physical activity
oxidative stress
gestational age