Differential Association of Mitochondrial DNA Haplogroups J and H With the Methylation Status of Articular Cartilage: Potential Role in Apoptosis and Metabolic and Developmental Processes.

Estefanía Cortés-PereiraJuan Fernández-TajesMercedes Fernández-MorenoMaría E Vázquez-MosqueraSara RelañoPaula Ramos-LouroAlejandro Durán-SotuelaAndrea Dalmao-FernándezNatividad OreiroFrancisco Javier Blanco Ignacio Rego Perez

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2019)

Mitochondrial DNA variation differentially associates with the methylation status of articular cartilage by acting on key mechanisms involved in osteoarthritis, such as apoptosis and metabolic and developmental processes.

Keyphrases

mitochondrial dna
copy number
genome wide
endoplasmic reticulum stress
cell cycle arrest
oxidative stress
dna methylation
cell death
rheumatoid arthritis
knee osteoarthritis
signaling pathway