Electroacupuncture improves apoptosis of nucleus pulposus cells via the IL-22/JAK2-STAT3 signaling pathway in a rat model of cervical intervertebral disk degeneration.

Sen YanLing-Yao XieXia-Xia DuanJia-Xuan TanSong YangLing MengQing-Hua ZhongWei-Di LinJia-Ni YangYao-Yao XiaoXueyu Jiang

Published in: Acupuncture in medicine : journal of the British Medical Acupuncture Society (2024)

We demonstrated that EA affected apoptosis by regulating the IL-22/JAK2-STAT3 pathway in NP cells and reducing inflammatory factors in the CIDD rat model. The results extend our knowledge of the mechanisms of action underlying the effects of EA as a potential treatment approach for CS in clinical practice.

Keyphrases

cell cycle arrest
induced apoptosis
pi k akt
endoplasmic reticulum stress
cell death
signaling pathway
oxidative stress
clinical practice
healthcare
cell proliferation
climate change
cerebral ischemia