Toll-like receptor inflammatory cascade and the development of diabetic kidney disease in children and adolescents with type 1 diabetes.
Thamara R de MeloKarla Simone Costa de SouzaMarcela Abbott Galvão UrurahyRaul Hernandes BortolinJoão Felipe BezerraMarcos Felipe de Oliveira GalvãoRosario Dominguez Crespo HirataMario Hiroyuki HirataRicardo Fernando ArraisMaria das Graças AlmeidaAdriana Augusto de RezendeVivian Nogueira SilbigerPublished in: Journal of paediatrics and child health (2022)
The increased mRNA expression of TLR2, TLR4, MYD88, NFKB, MCP1/CCL2 and IL18 favours the development of an inflammatory process that may lead to a decline in renal function and consequently DKD in children and adolescents with T1D. This suggests that these genes are early mediators of onset DKD since the beginning of the lives of the paediatric T1D patients.