Elucidating the cellular mechanism for E2-induced dermal fibrosis.

DeAnna Baker FrostAlisa SavchenkoAdeyemi OgunleyeMilton ArmstrongCarol Feghali-Bostwick

Published in: Arthritis research & therapy (2021)

We conclude that E2-induced dermal fibrosis occurs in part through induction of TGFβ1, 2, and Col22A1, which is regulated through EGR1 and the MAPK pathway. Thus, blocking estrogen signaling and/or production may be a novel therapeutic option in pro-fibrotic diseases.

Keyphrases

high glucose
diabetic rats
oxidative stress
signaling pathway
drug induced
transcription factor
cell proliferation
idiopathic pulmonary fibrosis
stress induced
pulmonary fibrosis