Glucose homeostasis is impaired in mice deficient in the neuropeptide 26RFa (QRFP).

Mouna El-MehdiSaloua TakhlidjtFayrouz KhiarGaëtan PrévostJean-Luc do RegoJean-Claude do RegoAlexandre BenaniEmmanuelle NedelecDavid GodefroyAranaud AraboBenjamin LefrancJérôme LeprinceYoussef AnouarNicolas ChartrelMarie Picot

Published in: BMJ open diabetes research & care (2021)

Disruption of the 26RFa gene induces substantial alteration in the regulation of glucose homeostasis, with in particular a deficit in insulin production by the pancreatic islets. These findings further support the notion that 26RFa is an important regulator of glucose homeostasis.

Keyphrases

radiofrequency ablation
blood glucose
type diabetes
glycemic control
genome wide
copy number
blood pressure
high fat diet induced
adipose tissue
skeletal muscle