Mesenchymal stem cell therapy for acute and chronic pancreatitis.
Kazumichi KawakuboShunsuke OhnishiMasaki KuwataniNaoya SakamotoPublished in: Journal of gastroenterology (2017)
Mesenchymal stem cells (MSCs) have attracted attention as a cell source for regenerative medicine. In particular, MSCs have an anti-inflammatory effect by secreting several kinds of bioactive molecules. MSC therapy is now being applied to various gastrointestinal diseases, such as graft-versus-host disease, inflammatory bowel disease, and liver cirrhosis. Therefore, MSC therapy has the potential to be a novel treatment for acute and chronic pancreatitis by suppressing inflammation. Several studies have investigated the effect of MSC therapy on acute and chronic pancreatitis, but the underlying mechanisms remain unknown. In this review, we summarize the present status of MSC therapy for acute and chronic pancreatitis.
Keyphrases
- mesenchymal stem cells
- liver failure
- respiratory failure
- umbilical cord
- aortic dissection
- cell therapy
- drug induced
- anti inflammatory
- bone marrow
- hepatitis b virus
- oxidative stress
- working memory
- climate change
- risk assessment
- intensive care unit
- combination therapy
- mechanical ventilation
- human health
- single molecule
- case control