Obesity and dyslipidemia are associated with partially reversible modifications to DNA hydroxymethylation of apoptosis- and senescence-related genes in swine adipose-derived mesenchymal stem/stromal cells.
Logan M GlasstetterTomiwa S OderindeMohit MirchandaniKamalnath Sankaran RajagopalanSamer H BarsomRoman ThalerSarosh SiddiqiXiang-Yang ZhuHui TangKyra L JordanIshran M SaadiqAndre J van WijnenAlfonso EirinLilach Orly LermanPublished in: Stem cell research & therapy (2023)
Obesity and dyslipidemia are associated with dysregulated DNA hydroxymethylation of apoptosis- and senescence-related genes in swine and human MSCs, potentially affecting cell vitality and regenerative functions. Vitamin-C may mediate reprogramming of this altered epigenomic landscape, providing a potential strategy to improve the success of autologous MSC transplantation in obese patients.
Keyphrases
- cell therapy
- obese patients
- endothelial cells
- weight loss
- bariatric surgery
- mesenchymal stem cells
- stem cells
- circulating tumor
- insulin resistance
- oxidative stress
- metabolic syndrome
- cell cycle arrest
- endoplasmic reticulum stress
- bone marrow
- roux en y gastric bypass
- dna damage
- type diabetes
- cell free
- gastric bypass
- high fat diet induced
- weight gain
- single molecule
- single cell
- cell death
- umbilical cord
- stress induced
- nucleic acid
- adipose tissue
- induced pluripotent stem cells
- circulating tumor cells
- physical activity
- tissue engineering