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Understanding Mechanisms of Response to CAR T-cell Therapy through Single-Cell Sequencing: Insights and Challenges.

Nicholas J HaradhvalaMarcela V Maus
Published in: Blood cancer discovery (2024)
Single-cell RNA sequencing has emerged as a powerful technique to understand the molecular features of chimeric antigen receptor (CAR) T cells that associate with clinical outcomes. Here we discuss the common themes that have emerged from across single-cell studies of CAR T-cell therapy, and summarize the challenges in interpreting this complex data type.
Keyphrases
  • single cell
  • cell therapy
  • rna seq
  • stem cells
  • high throughput
  • mesenchymal stem cells
  • electronic health record
  • big data