DNA damage repair gene germline profiling for metastatic prostate cancer patients of different ancestries.

Bilal AbdiNoemie BassetEmmanuel PerrotMarc-Antoine BenderraAhmed KhalilStephane OudardPascal BlanchetLaurent BrureauFlorence CouletOlivier CussenotGeraldine Cancel-Tassin

Published in: The Prostate (2022)

We showed that, in France, BRCA2 and ATM are the main predisposing DDR genes in mPC patients, with a particular aggressiveness for BRCA2 leading to early metastatic stage and death.

Keyphrases

dna damage
prostate cancer
dna repair
squamous cell carcinoma
small cell lung cancer
end stage renal disease
genome wide
newly diagnosed
ejection fraction
oxidative stress
peritoneal dialysis
prognostic factors
radical prostatectomy
genome wide identification
copy number
single cell
dna damage response