Tea polyphenol carrier-enhanced dexamethasone nanomedicines for inflammation-targeted treatment of rheumatoid arthritis.
Zeng YiYaqin RanXiangyu ChenQiulan TongLei MaYunfei TanXiaomin MaXudong LiPublished in: Journal of materials chemistry. B (2023)
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by synovial inflammation, cartilage damage and bone erosion. In the progression of RA, the inflammatory mediators including ROS, NO, TNF-α, and IL-6 play important roles in the aggravation of inflammation. Hence, reducing the generation and release of inflammatory mediators is of great importance. However, the high dose and frequent administration of clinical anti-inflammatory drugs such as glucocorticoids (GCs) usually lead to severe side effects. The development of nanotechnology provides a promising strategy to overcome these issues. Here, polyphenol-based nanoparticles with inherent anti-oxidative and anti-inflammatory activities were developed and used as a kind of nanocarrier to deliver dexamethasone (Dex). The in vitro experiments confirmed that the nanoparticles and drugs could act synergistically for suppressing inflammatory mediators in the LPS/INF-γ-induced inflammatory cell model. After intravenous administration, the Dex-loaded nanoparticles with good biosafety showed effective accumulation in inflamed joints and improved therapeutic efficacy by inducing anesis of synovial inflammation and cartilage destruction over free Dex in a collagen-induced arthritis (CIA) mouse model. The results demonstrated that polyphenol-based nanoparticles with therapeutic functions may serve as an innovative platform to synergize with chemotherapeutic agents for enhanced treatment of inflammatory diseases.
Keyphrases
- oxidative stress
- rheumatoid arthritis
- high dose
- diabetic rats
- disease activity
- mouse model
- anti inflammatory
- dna damage
- drug delivery
- low dose
- drug induced
- ankylosing spondylitis
- interstitial lung disease
- high glucose
- cancer therapy
- stem cells
- stem cell transplantation
- cell therapy
- high throughput
- extracellular matrix
- endothelial cells
- inflammatory response
- combination therapy
- anti inflammatory drugs
- early onset
- body composition
- postmenopausal women
- bone marrow
- stress induced