Effects of mutant huntingtin inactivation on Huntington disease-related behaviours in the BACHD mouse model.

Rachel Y CheongBarbara BaldoMuhammad U SajjadDeniz KirikÅsa Petersén

Published in: Neuropathology and applied neurobiology (2021)

Our results indicate that widespread targeting and the timing of interventions aimed at reducing mutant HTT are important factors to consider when developing disease-modifying therapies for HD.

Keyphrases

mouse model
wild type
physical activity
cancer therapy
drug delivery