Differential impact of intratumor heterogeneity (ITH) on survival outcomes in early-stage lung squamous and adenocarcinoma based on tumor mutational burden (TMB).
Stanislav FridlandHye Sung KimYoung Kwang ChaePublished in: Translational lung cancer research (2024)
There are significant differences in clinical outcomes, driver mutations, and the TME between high and low ITH groups among early-stage NSCLC patients. These differences may have treatment implications, necessitating further validation in other NSCLC datasets.
Keyphrases
- early stage
- small cell lung cancer
- end stage renal disease
- ejection fraction
- newly diagnosed
- chronic kidney disease
- advanced non small cell lung cancer
- squamous cell carcinoma
- prognostic factors
- single cell
- radiation therapy
- low grade
- locally advanced
- replacement therapy
- tyrosine kinase
- epidermal growth factor receptor