Performance of clinicopathologic models in men with high risk localized prostate cancer: impact of a 22-gene genomic classifier.

Jeffrey J TosoianSamuel R BirerR Jeffrey KarnesJingbin ZhangElai DavicioniEric E KleinStephen J FreedlandSheila WeinmannBruce J TrockRobert T DessShuang G ZhaoWilliam C JacksonKosj YamoahAlan Dal PraBrandon A MahalTodd M Morgan Rohit MehraSamuel KaffenbergerSimpa S SalamiChristopher KaneAlan PollackRobert B DenAlejandro BerlinEdward M SchaefferPaul L NguyenFelix Y FengDaniel E Spratt

Published in: Prostate cancer and prostatic diseases (2020)

Among men with high-risk prostate cancer, conventional clinico-pathologic data had poor discrimination to risk stratify development of metastatic disease. GC score was a significant and independent predictor of metastasis and may help identify men best suited for treatment intensification/de-escalation.

Keyphrases

prostate cancer
radical prostatectomy
middle aged
copy number
squamous cell carcinoma
small cell lung cancer
genome wide
neoadjuvant chemotherapy
open label
dna methylation
transcription factor
locally advanced
study protocol
data analysis
replacement therapy
artificial intelligence