Perfluorocarboxylic Anhydrides Triggered Cyclization: Access to 4-Perfluoroalkylpyridines.

A double nucleophilic addition-cyclization-elimination cascade is developed, that allows various 2,6-diaryl-4-perfluoroalkylpyridines to be synthesized in one step from easily available enamides and perfluorocarboxylic anhydrides. The procedure is also operationally simple and scalable and provides access to the facial construction of 4-fluoroalkylpyridines, which are of great interest in medicinal chemistry.